Architect's depiction of UCL Neuroscience building at Gray's Inn Road, London, constructed by ISG ltd

UCL Neuroscience, Construction and Refurbishment, London, UK

Finding a cure for dementia at the world-renowned institution UCL’s new home for neuroscience.
  • Customer
    University College London
  • Value
  • Project Manager
  • Structural Engineer
  • Area
    17,500 sqm
  • Architect
  • ME Engineer
    Hoare Lea
UCL main ISG 1


For long-term client, UCL, we are transforming the former Eastman Dental Institute (EDI) into a new world-leading £300m home for neuroscience in London. The landmark facility at 256 Grays Inn Road, London, will bring together over 500 research scientists, clinicians and patients to create a world-class research and treatment environment to tackle neurological diseases like dementia, which now count as the world’s leading cause of disability.
UCL main ISG 2

The project

As main contractor on the 17,500m2 facility, we are delivering one of the construction industry’s most complex basement structures and the excavation and recycling of 51,000m3 of London clay.

With demolition and construction of the eight-storey concrete building now underway, the transformative scheme will provide:

  • clinical care for local people with neurological diseases and as well as apprenticeships, work experience, mentoring schemes, an outreach programme and jobs for the local community;
  • a £10 million boost to the local economy;
  • a NHNN outpatient facility and an MRI scanning facility;
  • and contributions to local transport, affordable housing and Community Partnership Plans with local charities and organisations.
Topping out of Neurocscience centre

'Topping out' ceremony

The project reached the highest point of the construction process, which was celebrated with a 'Topping out' ceremony in May 2023.

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Making it happen

Once complete in 2024, it will be home to three bodies: the world-leading UCL Queen Square Institute of Neurology; the headquarters of the UK Dementia Research Institute, the UK’s largest investment in dementia; and the UCLH National Hospital for Neurology and Neurosurgery (NHNN) – the UK's largest dedicated neurological and neurosurgical hospital.

Key works included relocating postgraduate and PhD dental students from the EDI to UCL’s Rockefeller Building before construction started. This required close coordination with Rockefeller building users during the complex refurbishment of the Victorian Grade-II listed building into state-of-the-art teaching and research facilities – all while the building remained operational.

“We are pleased to be working with ISG on our Estates Transformation programme to create a new research and clinical environment for neurological diseases, where patients, clinicians and academics can come together in a state-of-the-art, collaborative, combined facility for the first time.” 

Kevin Argent, Director of Estates Development